monitoring of cyclosporine a blood levels in clinical settings

Monitoring of Cyclosporine A Blood Levels in Clinical Settings

I would like to comment on the paper by Beiraghdar et al. (1). C2 is regarded as a better indicator of cyclosporine A (CsA) exposure compared to C0 (2), this is also the case in pediatric patients (3). However, in clinical settings, C0 monitoring seems to be more reliable. It is connected to the fact that, CsA blood concentration is quite stable for between 10 and 12 hours after administration,...

Nurses’ experiences of humour in clinical settings

  Background: Providing holistic nursing care when there is a shortage of personnel and equipment exposes nurses to stress and a higher risk of occupational burnout. Humour can promote nurses’ health and influence nursing care. The aim of this study was to describe nurses’ experiences of humour in clinical settings and factors affecting it.   Methods : This qualitative study investigated nurses...

Effect of troglitazone on cyclosporine whole blood levels.

Troglitazone (TGZ; Rezulin, Parke-Davis, Morris Plains, NJ) is a thiazolidinedione antihyperglycemic agent that has been shown to decrease hemoglobin A1c and decrease insulin requirements in patients with type 2 diabetes (1-4). It increases tissue sensitivity to insulin and decreases hepatic glucose production but does not increase insulin secretion (5). At doses used clinically, troglitazone d...

monitoring cyclosporine absorption: a step beyond therapeutic drug monitoring

Electrolytes Disturbance and Cyclosporine Blood Levels among Kidney Transplant Recipients

BACKGROUND Kidney transplantation is associated with various biochemical abnormalities such as changes in serum blood level of sodium (Na), potassium (K), calcium (Ca), and phosphorous (P). Although cyclosporine (CsA) is used commonly, the prevalence of its side effects, including electrolytes disturbance, is not well understood. OBJECTIVE To find the prevalence of electrolytes disturbance an...

Marginalization of Professionalism in Clinical Settings; A qualitative study at Tehran University of Medical Sciences

Background: Management-level challenges are among the factors that undermine the individuals' adherence to professional behavior in clinical settings. This study investigated glitches of the management system in clinical settings from the perspective of staff, faculty members, and medical students/residents in hospitals affiliated to Tehran University of Medical Sciences. Methods: This qualita...